Oprah is a misspelling of the biblical Orpah (Hebrew, "fawn" or "back of the neck") — Naomi's daughter-in-law in the Book of Ruth. The midwife transposed the letters on Oprah Winfrey's 1954 birth certificate, and the misspelled name stuck. Oprah Winfrey (born 1954) — the first Black female billionaire, the most influential talk show host in television history (1986-2011), and the most generous philanthropist in entertainment ($400 million+ donated). Her 1988 "Wagon of Fat" Diet episode is the most-watched episode in talk show history. Founded OWN (Oprah Winfrey Network) in 2011; Presidential Medal of Freedom (2013).
Subject of Kitty Kelley's Oprah: A Biography (2010).
Oprah does not currently appear in the US Social Security Administration's top 1,000 girls' names, so we don't publish a US rank or birth count for it. That says nothing about the name's standing elsewhere in the world — only that it sits outside the ranked US data we rely on.
In Pythagorean numerology the letters of Oprah reduce to 4, The Builder. This is a traditional interpretive system, not a factual claim about the name.